Aging : increased responsiveness of colorectal mucosa to carcinogen stimulation and protective role of folic acid
作者： Y. M. Nensey , F. L. Arlow , A. P. N. Majumdar
DOI: 10.1007/BF02065427
关键词:
摘要: Recent investigations have demonstrated a protective role for folic acid in dysplasia and neoplasia, through an unknown mechanism. The current study was designed to evaluate whether the of is due, part, its antiproliferative properties. In addition, because colorectal neoplasia more common with increasing age, we compared results both old (22 months) young (3 rats. Colorectal mucosal explants rats treated known carcinogen methylazoxymethanol, were supplemented acid. Ornithine decarboxylase then measured as index cellular proliferative activity. We observed that supplemental suppressed carcinogen-induced ornithine activity by 64% 74% Furthermore, similar phenomenon tyrosine kinase, which comparison. suppression hyperproliferative may contribute effect neoplasia.
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