Constitutive fragile sites and cancer.

作者: J. Yunis , A. Soreng

DOI: 10.1126/SCIENCE.6239375

关键词:

摘要: Breaks were observed at 51 sites in homologous chromosomes lymphocytes from ten humans and two great apes when cells deprived of thymidine. The incidence breaks was enhanced by caffeine, a substance that inhibits DNA repair replicating cells. locations 20 correlated with breakpoints have been related to human malignancy.

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