Comparative genomic hybridization and telomerase activity analysis identify two biologically different groups of 4s neuroblastomas
作者： C Brinkschmidt , C Poremba , H Christiansen , R Simon , KL Schäfer
DOI: 10.1038/BJC.1998.370
关键词:
摘要: Chromosomal aberrations of 20 stage 4s neuroblastomas were analysed by comparative genomic hybridization (CGH). In a subset 13/20 tumours, telomerase activity was evaluated the telomeric repeat amplification protocol (TRAP). The CGH data compared with results ten 1 and 2 (stage 1/2) 22 3 4 3/4) neuroblastomas. A total 17/20 did not progress clinically, whereas tumour progression lethal outcome occurred in 3/20 cases. clinically non-progressing tumours revealed high rate whole-chromosome (73.4%) an overrepresentation mainly chromosomes 2, 6, 7, 12, 13, 17, 18 underrepresentation 3, 4, 11, 14. MYCN or 1p deletion observed only 1/27 2/17 respectively, all three progressive showed amplification, and, 2/3 cases, distal 17q gains. Except for one case, contrast, elevated levels. Our suggest that belong to two biologically different groups, which displays genetic features localized 1/2 other mimics advanced 3/4
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sci-hub.se 参考文章(10)
K C Healy, Telomere dynamics and telomerase activation in tumor progression: prospects for prognosis and therapy. Oncology Research. ,vol. 7, pp. 121- 130 ,(1995)
A Kallioniemi, O. Kallioniemi, D Sudar, D Rutovitz, J. Gray, F Waldman, D Pinkel, Comparative Genomic Hybridization for Molecular Cytogenetic Analysis of Solid Tumors Science. ,vol. 258, pp. 818- 821 ,(1992) , 10.1126/SCIENCE.1359641
Yasuhide Hayashi, Toshiya Inaba, Ryoji Hanada, Masao Yamada, Yasuo Nakagome, Keiko Yamamoto, Similar chromosomal patterns and lack of N-myc gene amplification in localized and IV-S stage neuroblastomas in infants. Medical and Pediatric Oncology. ,vol. 17, pp. 111- 115 ,(1989) , 10.1002/MPO.2950170208
H Christiansen, F Lampert, Tumour karyotype discriminates between good and bad prognostic outcome in neuroblastoma. British Journal of Cancer. ,vol. 57, pp. 121- 126 ,(1988) , 10.1038/BJC.1988.24
Maria Łastowska, Elizabeth Nacheva, Angela McGuckin, Ann Curtis, Colin Grace, Andrew Pearson, Nick Bown, , Comparative genomic hybridization study of primary neuroblastoma tumors Genes, Chromosomes and Cancer. ,vol. 18, pp. 162- 169 ,(1997) , 10.1002/(SICI)1098-2264(199703)18:3<162::AID-GCC2>3.0.CO;2-#
Eiso Hiyama, Keiko Hiyama, Takashi Yokoyama, Yuichiro Matsuura, Mieczyslaw A. Piatyszek, Jerry W. Shay, Correlating telomerase activity levels with human neuroblastoma outcomes Nature Medicine. ,vol. 1, pp. 249- 255 ,(1995) , 10.1038/NM0395-249
Peter C. G. Wilson, Max J. Coppes, Hassan Solh, Helen S. L. Chan, Derek Jenkin, Mark L. Greenberg, Sheila Weitzman, Neuroblastoma stage IV-S: a heterogeneous disease. Medical and Pediatric Oncology. ,vol. 19, pp. 467- 472 ,(1991) , 10.1002/MPO.2950190604
Stanislas du Manoir, Evelin Schröck, Martin Bentz, Michael R. Speicher, Stefan Joos, Thomas Ried, Peter Lichter, Thomas Cremer, Quantitative analysis of comparative genomic hybridization Cytometry. ,vol. 19, pp. 27- 41 ,(1995) , 10.1002/CYTO.990190105
Stanislas du Manoir, Michael R. Speicher, Stefan Joos, Evelin Schröck, Susanne Popp, Hartmut Döhner, Gyula Kovacs, Michel Robert-Nicoud, Peter Lichter, Thomas Cremer, Detection of complete and partial chromosome gains and losses by comparative genomic in situ hybridization Human Genetics. ,vol. 90, pp. 590- 610 ,(1993) , 10.1007/BF00202476
Robert C. Seeger, Garrett M. Brodeur, Harland Sather, Andree Dalton, Stuart E. Siegel, Kwan Y. Wong, Denman Hammond, Association of multiple copies of the N-myc oncogene with rapid progression of neuroblastomas. The New England Journal of Medicine. ,vol. 313, pp. 1111- 1116 ,(1985) , 10.1056/NEJM198510313131802