High Telomerase Reverse Transcriptase (hTERT) Messenger RNA Level Correlates with Tumor Recurrence in Patients with Favorable Histology Wilms’ Tumor

摘要: Telomerase is a reverse transcriptase that maintains chromosome ends, compensating for the progressive loss of DNA occurs during replication. High telomerase enzyme activity an unfavorable prognostic feature several types cancers. We investigated whether level predicts outcome patients with pediatric renal malignancy Wilms’ tumor. In case-cohort study 78 favorable histology tumor, we compared tumor levels in and without eventual recurrence. Three measures were used: ( ) activity; b expression hTR, RNA component telomerase; c mRNA hTERT , gene encodes catalytic enzyme. Of evaluable samples, 81% had detectable activity, 97% transcript, 100% hTR. Weak correlations observed between hTR r = 0.34, P 0.02) 0.32, 0.04). variables assessed, only correlated outcome. The median tumors recurrence was higher than (1.42 versus 0.97 units, 0.023, Wilcoxon). Univariate analysis as continuous variable suggested each unit increase increased risk (RR) by factor 1.66 [95% confidence interval (CI), 1.2–2.3; 2 units RR 6.40 (95% CI, 1.49–27.67, 0.013). Multivariate predictor recurrence, adjusted stage age at diagnosis, revealed 1.48 0.9–2.6; 0.16). Measurement may, therefore, enable clinicians to identify population high adjust their therapy accordingly. A larger will be necessary determine independent indicator. Further biological investigation warranted discern link prognosis causative or correlative.