Telomerase activity and the expression of telomerase components in acute myelogenous leukaemia
作者： Dawei XU , Astrid Gruber , Curt Peterson , Pavel Pisa
DOI: 10.1046/J.1365-2141.1998.00969.X
关键词:
摘要: In 95 leukaemic cell samples from 66 patients with acute myelogenous leukaemia (AML) (47 de novo and 19 secondary AML) telomerase activity was determined the expression of components: reverse transcriptase (hTERT), RNA template (hTR) telomerase-associated protein (TP1) evaluated by RT-PCR. Compared to peripheral blood mononuclear cells (PBMC) normal adult 87% (82/95) patient exhibited elevated activity. hTERT, but not hTR TP1 strongly correlated levels (r = 0.47, P < 0.0001). The were significantly higher at time relapse or progression than diagnosis (P = 0.003), CD34 chromosomal abnormalities (P = 0.01 P = 0.001 respectively). rate duration complete remission (CR) did correlate diagnosis. Among eight in first relapse, however, two three low re-entered CR, whereas none five high achieved a second CR. Taken together, activation/up-regulation AML is disease progression-associated event. Undifferentiated status aberration also lead up-regulation AML.
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