Telomere Reduction of Specific Chromosome Translocation in Acute Myelocytic Leukemia
作者： Katsuhiko Takauchi , Satoshi Tashiro , Megu Ohtaki , Nanao Kamada
DOI: 10.1111/J.1349-7006.1994.TB02071.X
关键词: Chromosomal translocation 、 Karyotype 、 Pathogenesis 、 Telomere 、 Restriction fragment 、 Southern blot 、 Myelocytic leukemia 、 Biology 、 Molecular biology 、 Leukemogenic
摘要: The length of telomere restriction fragments (TRF) was studied by Southern blotting in 42 patients with acute myelocytic leukemia (AML) including 15 8;21 translocation, 8 15;17 translocation and 19 a normal karyotype. TRF leukemic cells karyotype or showed significant reduction compared to that lymphocytes from individuals (P < 0.05). In addition, there statistically difference between Therefore, the may be an important factor leukemogenic process.
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