Salivary antimicrobial peptides (LL-37 and alpha-defensins HNP1–3), antimicrobial and IgA responses to prolonged exercise

摘要: There are many factors in mucosal secretions that contribute to innate immunity and the 'first line of defence' at surfaces. Few studies, however, have investigated effects exercise on these 'defence' factors. The aim present study was determine acute prolonged salivary levels selected antimicrobial peptides (AMP) not yet been studied response (HNP1-3 LL-37) addition immunoglobulin A (IgA). secondary objective assess saliva antibacterial capacity. Twelve active men exercised a cycle ergometer for 2.5 h approximately 60% maximal oxygen uptake. Unstimulated whole samples were obtained before after exercise. significant decrease (P < 0.05) IgA:osmolality ratio, following exercise, but IgA concentration secretion rate unaltered. Salivary HNP1-3 LL-37 concentrations 0.01 P 0.05, respectively), concentration:osmolality ratios 0.01) rates all increased capacity (against E. coli) did change. AMPs may confer some benefit could result from synergistic compensation within immune system and/or airway inflammation epithelial damage. Further is required significance such changes overall how this influences risk infection.