Studies Toward the Synthesis of (−)-Zampanolide: Preparation of N-Acyl Hemiaminal Model Systems
作者： Dawn M. Troast , John A. Porco
DOI: 10.1021/OL025558L
关键词:
摘要: Synthesis of N-acyl hemiaminal model systems related to the side chain antitumor natural product zampanolide is reported. Key steps involve oxidative decarboxylation N-acyl-α-amino acid intermediates, followed by ytterbium triflate mediated solvolysis. Evidence for stabilization moiety in compounds an intramolecular hydrogen-bonding network described.
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