Inhibition of metalloproteinase activity by fruit extracts.

作者: Patricia Tate , Jason God , Robert Bibb , Qi Lu , Lyndon L. Larcom

DOI: 10.1016/J.CANLET.2004.03.025

关键词:

摘要: While the metalloproteinase enzymes are essential for development and remodeling of tissues, aberrant over expression these contributes to several pathologic conditions. In particular, in cancer plays a significant role metastasis by providing mechanism invasion spread. The data presented here indicate that water extracts raspberries, blackberries muscadine grapes inhibit activities metalloproteinases 2 9. This inhibition could contribute suppression carcinogenesis diets high fruit content.

参考文章(28)
L. M. Matrisian, W. H. Rodgers, R. A. Jensen, K. J. Heppner, Expression of most matrix metalloproteinase family members in breast cancer represents a tumor-induced host response. American Journal of Pathology. ,vol. 149, pp. 273- 282 ,(1996)
Hideaki Nagase, J. F. Woessner, Matrix metalloproteinases and TIMPs ,(2000)
Shigeyoshi Itohara, Masatoshi Tanioka, Hiroshi Yoshida, Hirofumi Nishimoto, Takeshi Itoh, Takayuki Yoshioka, Reduced angiogenesis and tumor progression in gelatinase A-deficient mice. Cancer Research. ,vol. 58, pp. 1048- 1051 ,(1998)
Hansjorg KOLKENBROCK, Dagmar ORGEL, Adelheid HECKER-KIA, Wolfgang NOACK, Norbert ULBRICH, The complex between a tissue inhibitor of metalloproteinases (TIMP-2) and 72-kDa progelatinase is a metalloproteinase inhibitor. FEBS Journal. ,vol. 198, pp. 775- 781 ,(1991) , 10.1111/J.1432-1033.1991.TB16080.X
Leslie Wada, Boxin Ou, Antioxidant activity and phenolic content of Oregon caneberries. Journal of Agricultural and Food Chemistry. ,vol. 50, pp. 3495- 3500 ,(2002) , 10.1021/JF011405L
Masaharu Makimura, Masatomo Hirasawa, Kihei Kobayashi, Jiro Indo, Senji Sakanaka, Takashi Taguchi, Shigeo Otake, Inhibitory Effect of Tea Catechins on Collagenase Activity Journal of Periodontology. ,vol. 64, pp. 630- 636 ,(1993) , 10.1902/JOP.1993.64.7.630
Zhi‐Ming Shao, Zhen‐Zhou Shen, Can‐Hui Liu, Maryam R Sartippour, Vay Liang Go, David Heber, Mai Nguyen, None, Curcumin exerts multiple suppressive effects on human breast carcinoma cells. International Journal of Cancer. ,vol. 98, pp. 234- 240 ,(2002) , 10.1002/IJC.10183
Boris Ratnikov, Elena Deryugina, Jay Leng, George Marchenko, Dale Dembrow, Alex Strongin, Determination of matrix metalloproteinase activity using biotinylated gelatin. Analytical Biochemistry. ,vol. 286, pp. 149- 155 ,(2000) , 10.1006/ABIO.2000.4798
Michel Demeule, Mathieu Brossard, Martine Pagé, Denis Gingras, Richard Béliveau, Matrix metalloproteinase inhibition by green tea catechins. Biochimica et Biophysica Acta. ,vol. 1478, pp. 51- 60 ,(2000) , 10.1016/S0167-4838(00)00009-1