Concomitant chemopreventive and antibacterial effects of some Iranian plants from the genus Cousinia (Asteraceae)

作者: Ahmad Reza Shahverdi , Mohammad Reza Khorramizadeh , Farideh Attar , Farshid Saadat , Sepideh Vahid

DOI: 10.1590/S0102-695X2007000300004

关键词:

摘要: During the past several years, various species of Cousinia (Asteraceae) have been authenticated in Iran. However, data concerning their biological activities remain limited. The main purpose this research was to assess potential cytotoxicity and matrix metalloproteinases (MMP) inhibitory effects seven ethanol extracts using a cell line model (Fibrosarcoma-WEHI 164). We further investigated antibacterial activity these extracts, disk diffusion method. Among total extract C. sulabadensis elicited significant inhibition MMP dose-response fashion (49.2 ± 0.51, p < 0.05). exhibited lowest effect at all tested concentrations. concentration necessary produce 50% death rate (IC50) with shulabadensis 304.5 0.61 µg/mL. calculated IC50 for other ranged between 18.4 0.59 87.9 0.58 highest observed phyllocephala. In conclusion, study supports that display remarkable activity. concomitant MMP-inhibitory low might coin future anti-invasive herbal medicine studies.

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