Nrf2-peroxiredoxin I axis in polymorphous adenocarcinoma is associated with low matrix metalloproteinase 2 level

摘要: Polymorphous adenocarcinoma (PAC) is a malignant epithelial neoplasm that affects almost exclusively the minor salivary glands, generally described as having relatively good prognosis. Aberrant nuclear factor erythroid 2 (NF-E2)-related (Nrf2) activation in tumor cells has been associated with induction of antioxidant enzymes, such peroxiredoxin I (Prx I) and increased matrix metalloproteinase (MMP) expression. In this context, aim present study was to evaluate expression Nrf2 correlate it Prx MMP-2 secretion PAC. Thirty-one cases PAC from oral biopsies were selected immunohistochemically analyzed for I. quantification performed on primary cell cultures derived Oral squamous carcinoma (OSCC) used control. A high immunoexpression observed both cytoplasm nucleus neoplastic Nuclear staining suggested its majority cells, which confirmed by target gene, Quantification showed lower levels when compared OSCC (p < 0.05). conclusion, although overexpression frequently high-grade malignancies, relationship not infallible and, fact, opposite may occur low-grade tumors, glands.