Mechanisms behind the atherothrombotic effects of acrolein, a review.

摘要: Cardiovascular diseases (CVDs) are the leading cause of death worldwide. The majority cardiovascular complications secondary to atherosclerosis. Extensive evidence has showed that environmental pollutants such as cigarette smoke and automobile exhaust increase risk developing Acrolein, a highly reactive unsaturated aldehyde, is found contaminant in air, food water. Investigations during last decades have shown acrolein via various mechanisms oxidative stress, enhancement inflammatory processes activation matrix metalloproteases can initiate accelerate atherosclerotic lesions formation. Furthermore, exposure been suggested induce or exacerbate systemic dyslipidemia, an important factor for development Finally, there reports which indicate platelet stimulation coagulation cascade subsequently leads thrombosis. Even modest reduction substantial effects on population health. Public health efforts reduce exposures from known sources may lower prevalence vascular disease. This review focuses potential pathways behind acrolein-induced atherothrombotic effects.