Biosynthesis of mercapturic acids from allyl alcohol, allyl esters and acrolein.

摘要: 1. 3-Hydroxypropylmercapturic acid, i.e. N-acetyl-S-(3-hydroxypropyl)-l-cysteine, was isolated, as its dicyclohexylammonium salt, from the urine of rats after subcutaneous injection each following compounds: allyl alcohol, formate, propionate, nitrate, acrolein and S-(3-hydroxypropyl)-l-cysteine. 2. Allylmercapturic N-acetyl-S-allyl-l-cysteine, isolated triallyl phosphate, sodium sulphate nitrate. The sulphoxide allylmercapturic acid detected in excreted by these rats. 3. identified g.l.c. a metabolite acetate, stearate, benzoate, diallyl phthalate, nitrite, phosphate sulphate. 4. S-(3-Hydroxypropyl)-l-cysteine bile rat dosed with acetate.