摘要: In 1969 I proposed a mechanism of biological Cyclophosphamide (CYM) activation ( 18) which is shown by figure 1. This pathway was concluded from circumstantial evidence that 4-carboxy-CYM the main CYM metabolite and C-4 atom molecule ring preferential site oxidation. assumed one metabolites should account for tumour specific activity drug. we could rule out concerning 4-carboxyCYM although this compound has been identified as Struck co-workers in addition to 4-keto-CYM, non toxic minor (27).
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