Angiotensin-Converting Enzyme Related-Polymorphisms on Inflammation, Muscle and Myocardial Damage After a Marathon Race.

摘要: Muscle damage is one of the most important factors that affect muscle fatigue during endurance exercise. Recent evidence suggests renin-angiotensin system impacts on skeletal wasting. The aim this study was to determine association between AGT Met235Thr, ACE I/D and BDKRB2 -9/+9 polymorphisms with inflammation, myocardial injury induced by Eighty-one Brazilian male runners participated in completed International Marathon Sao Paulo. markers (alanine transaminase, ALT, aspartate AST, lactic dehydrogenase, LDH, creatine kinase, CK, Troponin, pro BNP, myoglobin, CK-MB) inflammatory mediators (IL-6, IL-8, IL-10, IL12p70, IL1β, TNF-α) were determined day before, immediately after, three days after event. also fifteen race angiotensinogen (AGT) angiotensin-converting enzyme (ACE) I/D, Bradykinin B2 receptor (BDKRB2) determined. participation an increase all evaluated (p 500U/I) CK levels higher for II genotypes (69%) compared DD ID (38% 40%, respectively) after. BNP IL-1β, IL-8 elevated MM genotype TT athletes and/or race. -9/-9 had pronounced response CK-MB ALT AST activities, troponin, IL-6, immediately, percentage responders (>500U/I) greater -9-9 -9+9 (46 48%, +9+9 (31%) II, MM, may susceptibility exercise could be used predict development clinical conditions associated injury.