Matrix-Assisted Transplantation of Functional Beige Adipose Tissue

摘要: Novel, clinically relevant, approaches to shift energy balance are urgently needed combat metabolic disorders such as obesity and diabetes. One promising approach has been the expansion of brown adipose tissues that express uncoupling protein (UCP) 1 thus can uncouple mitochondrial respiration from ATP synthesis. While UCP1-expressing depots may be achieved in rodents via genetic pharmacological manipulations or transplantation fat depots, these methods difficult use for human clinical intervention. We present a novel cell scaffold technology optimized establish functional fat-like vivo. adapted biophysical properties hyaluronic acid-based hydrogels support differentiation white tissue-derived multipotent stem cells (ADMSCs) into lipid-accumulating, beige tissue. Subcutaneous implantation ADMSCs within resulted establishment distinct implants successfully attracted host vasculature persisted several weeks. Importantly, implant recipients demonstrated elevated core body temperature during cold challenges, enhanced rates, improved glucose homeostasis, reduced weight gain, demonstrating therapeutic merit this highly translatable approach. This is first truly system unlock potential tissue expansion.