LSD1 Interacts with Zfp516 to Promote UCP1 Transcription and Brown Fat Program
作者： Audrey Sambeat , Olga Gulyaeva , Jon Dempersmier , Kevin M. Tharp , Andreas Stahl
DOI: 10.1016/J.CELREP.2016.05.019
关键词:
摘要: Zfp516, a brown fat (BAT)-enriched and cold-inducible transcription factor, promotes of UCP1 other BAT-enriched genes for non-shivering thermogenesis. Here, we identify lysine-specific demethylase 1 (LSD1) as direct binding partner Zfp516. We show that, through interaction with LSD1 is recruited to BAT-enriched genes, such PGC1α, function coactivator by demethylating H3K9. also that induced during adipogenesis its activity required the BAT program. Furthermore, ablation in mice using Myf5-Cre alters embryonic development. Moreover, BAT-specific deletion via use UCP1-Cre impairs program development, making resemble WAT, reducing thermogenic promoting obesity. Finally, demonstrate an in vivo requirement Zfp516-LSD1 gene activation.
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sci-hub.se 参考文章(28)
Jianxun Wang, Francesca Telese, Yuliang Tan, Wenbo Li, Chunyu Jin, Xin He, Harihar Basnet, Qi Ma, Daria Merkurjev, Xiaoyan Zhu, Zhijie Liu, Jie Zhang, Kenny Ohgi, Havilah Taylor, Ryan R White, Cagdas Tazearslan, Yousin Suh, Todd S Macfarlan, Samuel L Pfaff, Michael G Rosenfeld, LSD1n is an H4K20 demethylase regulating memory formation via transcriptional elongation control Nature Neuroscience. ,vol. 18, pp. 1256- 1264 ,(2015) , 10.1038/NN.4069
Kevin M Tharp, Amit K Jha, Judith Kraiczy, Alexandra Yesian, Grigory Karateev, Riccardo Sinisi, Elena A Dubikovskaya, Kevin E Healy, Andreas Stahl, None, Matrix-Assisted Transplantation of Functional Beige Adipose Tissue Diabetes. ,vol. 64, pp. 3713- 3724 ,(2015) , 10.2337/DB15-0728
Philippe Soriano, Mats Hellström, Karin E. Weismann, Michelle D. Tallquist, Early myotome specification regulates PDGFA expression and axial skeleton development. Development. ,vol. 127, pp. 5059- 5070 ,(2000) , 10.1242/DEV.127.23.5059
David J. Orlicky, Jerome Schaack, Adenovirus transduction of 3T3-L1 cells Journal of Lipid Research. ,vol. 42, pp. 460- 466 ,(2001) , 10.1016/S0022-2275(20)31671-0
Jun Eguchi, Xun Wang, Songtao Yu, Erin E. Kershaw, Patricia C. Chiu, Joanne Dushay, Jennifer L. Estall, Ulf Klein, Eleftheria Maratos-Flier, Evan D. Rosen, Transcriptional control of adipose lipid handling by IRF4. Cell Metabolism. ,vol. 13, pp. 249- 259 ,(2011) , 10.1016/J.CMET.2011.02.005
Jianxun Wang, Kathleen Scully, Xiaoyan Zhu, Ling Cai, Jie Zhang, Gratien G. Prefontaine, Anna Krones, Kenneth A. Ohgi, Ping Zhu, Ivan Garcia-Bassets, Forrest Liu, Havilah Taylor, Jean Lozach, Friederike L. Jayes, Kenneth S. Korach, Christopher K. Glass, Xiang-Dong Fu, Michael G. Rosenfeld, Opposing LSD1 complexes function in developmental gene activation and repression programmes Nature. ,vol. 446, pp. 882- 887 ,(2007) , 10.1038/NATURE05671
Aaron M. Cypess, Sanaz Lehman, Gethin Williams, Ilan Tal, Dean Rodman, Allison B. Goldfine, Frank C. Kuo, Edwin L. Palmer, Yu-Hua Tseng, Alessandro Doria, Gerald M. Kolodny, C. Ronald Kahn, Identification and Importance of Brown Adipose Tissue in Adult Humans The New England Journal of Medicine. ,vol. 360, pp. 1509- 1517 ,(2009) , 10.1056/NEJMOA0810780
Delphine Duteil, Eric Metzger, Dominica Willmann, Panagiota Karagianni, Nicolaus Friedrichs, Holger Greschik, Thomas Günther, Reinhard Buettner, Iannis Talianidis, Daniel Metzger, Roland Schüle, LSD1 promotes oxidative metabolism of white adipose tissue Nature Communications. ,vol. 5, pp. 4093- 4093 ,(2014) , 10.1038/NCOMMS5093
Stephen R. Farmer, Be cool, lose weight Nature. ,vol. 458, pp. 839- 840 ,(2009) , 10.1038/458839A
S Collins, E Yehuda-Shnaidman, H Wang, Positive and negative control of Ucp1 gene transcription and the role of β-adrenergic signaling networks. International Journal of Obesity. ,vol. 34, ,(2010) , 10.1038/IJO.2010.180