Circulating clonal lymphocytes in myeloma constitute a minor subpopulation of B cells.

摘要: The mononuclear cells in the blood of myeloma patients have been reported to contain a high proportion phenotypically abnormal B lymphocytes. These proposed constitute drug-resistant proliferative cell compartment. To determine extent lymphocyte involvement, clonotypic among CD19-expressing from was estimated by quantitative polymerase chain reaction analysis third complementarity determining region (CDR3). results indicate that lymphocytes constitute, on average, 6% cells, and only minor fraction these are clonally related cells. While small number circulating clonal is not incompatible with their role as reservoir proliferating progenitors, majority appear be