Circulating B lymphocytes in multiple myeloma patients contain an autocrine IL-6 driven pre-myeloma cell population.
作者： X. Thomas , H. Q. Xiao , R. Chang , J. Epstein
DOI: 10.1007/978-3-642-77633-5_24
关键词:
摘要: Among the unanswered questions in development of multiple myeloma are level hematopoietic stem cell,1 tissue site initiation (bone marrow? lymph node?) 2,3 and role IL-6 development. 4-6 The involvement B lymphocytes bone marrow blood has been suggested initially by identifying cells displaying concordant isotype idiotype, 7-9 followed demonstration a circulating clonal cell population with JH rearrangement.10 Abnormal from patients could be differentiated into upon stimulation,11 first functional involvement. Similarly, mononuclear cultured IL-3 IL-612 or co-cultured autologous stromal cells13 plasma containing monotypic immunoglobulin.
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