Low free testosterone levels in rheumatoid arthritis.

作者: T D Spector , L A Perry , G Tubb , A J Silman , E C Huskisson

DOI: 10.1136/ARD.47.1.65

关键词:

摘要: The androgen status of 25 male patients with rheumatoid arthritis (RA) was assessed and compared that age matched controls osteoarthritis (OA). Significantly reduced levels serum free testosterone were found in the RA group. Within group unrelated to all indices disease activity measured, though it strongly related latex positivity. These results support hypothesis sex hormones may have a protective role RA, prospective studies would be necessary determine whether relation one cause or effect.

参考文章(15)
Robert G. Lahita, Sex steroids and the rheumatic diseases. Arthritis & Rheumatism. ,vol. 28, pp. 121- 126 ,(1985) , 10.1002/ART.1780280202
Maurizio Cutolo, Enrico Balleari, Silvano Accardo, Elpis Samanta, Marco A. Cimmino, Massimo Giusti, Mario Monachesi, Agnese Lomeo, Preliminary results of serum androgen level testing in men with rheumatoid arthritis. Arthritis & Rheumatism. ,vol. 27, pp. 958- 959 ,(1984) , 10.1002/ART.1780270821
A.G. Everson Pearse, The hypophysis in rheumatoid arthritis. The Lancet. ,vol. 255, pp. 954- 955 ,(1950) , 10.1016/S0140-6736(50)90786-0
Robert D. Inman, Immunologic sex differences and the female predominance in systemic lupus erythematosus Arthritis & Rheumatism. ,vol. 21, pp. 849- 852 ,(1978) , 10.1002/ART.1780210718
Maxime Dougados, Khalil Nahoul, Laurent Benhamou, Bernard Amor, Androgen plasma levels in female rheumatoid arthritis patients. Arthritis & Rheumatism. ,vol. 26, pp. 935- 936 ,(1983) , 10.1002/ART.1780260727
LAWRENCE N. PARKER, ELLIS R. LEVIN, ERIC T. LIFRAK, Evidence for adrenocortical adaptation to severe illness. The Journal of Clinical Endocrinology and Metabolism. ,vol. 60, pp. 947- 952 ,(1985) , 10.1210/JCEM-60-5-947
N. C. Wathen, L. A. Perry, E. Rubenstein, T. Chard, A relationship between sex hormone binding globulin and dehydroepiandrosterone sulfate in normally menstruating females. Gynecological Endocrinology. ,vol. 1, pp. 47- 50 ,(1987) , 10.3109/09513598709082695
ATHENA LINOS, JOHN W. WORTHINGTON, MICHAEL O'FALLON, LEONARD T. KURLAND, THE EPIDEMIOLOGY OF RHEUMATOID ARTHRITIS IN ROCHESTER MINNESOTA: A STUDY OF INCIDENCE, PREVALENCE, AND MORTALITY American Journal of Epidemiology. ,vol. 111, pp. 87- 98 ,(1980) , 10.1093/OXFORDJOURNALS.AJE.A112878