Transcriptional Regulation of Vascular Endothelial Growth Factor Expression in Epithelial and Stromal Cells during Mouse Mammary Gland Development

作者: Russell C. Hovey , Anita S. Goldhar , Judit Baffi , Barbara K. Vonderhaar

DOI: 10.1210/MEND.15.5.0635

关键词:

摘要: Accompanying changes in the development and function of mammary gland is establishment a vascular network critical importance for lactogenesis tumorigenesis. A potent angiogenic permeability factor that regulates association with epithelial-stromal interactions endothelial growth (VEGF). Analysis VEGF transcription by RT-PCR revealed mRNA all three isoforms (VEGF120, 164, 188) within nulliparous females. During pregnancy level VEGF188 declined became undetectable during lactation increased abundance VEGF120 VEGF164 mRNAs. All were expressed at consistent levels cleared fat pad throughout development. Furthermore, presence omental adipose tissue various stages established specifically gland. Using 3T3-L1 preadipocytes it was demonstrated VEGF1...

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