An epidemiological study of the susceptibility and frequency of multiple-drug-resistant strains of Pseudomonas aeruginosa isolated at medical institutes nationwide in Japan

摘要: The susceptibility of 3233 strains Pseudomonas aeruginosa, isolated primarily in 2001, as agents infection at 37 medical institutes with various specialties seven regions Japan (ranging from Hokkaido to Kyushu/Okinawa), 18 antipseudomonal known be active against P. aeruginosa was evaluated, accordance the National Committee for Clinical Laboratory Standards (NCCLS) guidelines. Of agents, including some combinations β-lactamase inhibitors and antibacterial ciprofloxacin had lowest minimum inhibitory concentration (MIC)50 (0.25 µg/ml) followed by meropenem, an MIC50 0.5 µg/ml. 7 examined (ceftazidime, cefozopran, imipenem, biapenem, gentamicin, tobramycin, levofloxacin) between 1 2 Among tested, tobramycin showed MIC90 (2 µg/ml), which not significantly different its (1 µg/ml). other ranged 8 64 µg/ml more. 12 covered NCCLS guidelines determined according standard method frequency resistant or relatively low (7.5%–8.3%). showing intermediate severe resistance particularly (8.0%). aztreonam, levofloxacin 16.7%–19.0%, about twice high tobramycin. pattern (isolated Japan) five piperacillin, ciprofloxacin) evaluated relation they were isolated. values these did differ among regions. However, ceftazidime gentamicin higher Kansai region than Tohoku, Kansai, Kyushu/Okinawa strains, 89 classified multiple-drug-resistant (imipenem, strains. 42 urine, 17 sputum pharyngeal mucus, 13 pus, blood, cerebrospinal fluid, specimens. Tohoku