Role of micronize purified flavonoid fraction and ethanol Graptophyllum pictum extract on experimental anal ulcer healing. Study on Wistar rat

摘要: Abstract Aim of the study To evaluate role micronized purified flavanoid fraction and ethanol Graptophyllum pictum extract in treatment anal ulcer. Method Twenty-eight Wistar rats were randomly allocated into four groups. Groups 2, 3 4 anus induced with croton oil, but was not on group 1. 1 2 treated normal saline, while groups fraction, G. extract, respectively. On 9th days blood sample taken from retro-orbital region, killed by cervical dislocation under ether anesthesia. The canal resected up 2 cm opening, weighted, photographically to measure percentage residual ulcer, then prepared for microscopic examination. Elisa methods done superoxide dismutase malondialdedhyde. total leukocyte specimen counted 400 magnification power. dismutase, coefficient, statistical analysis using ANOVA LSD, malondialdedhyde ulcers Kruskal–Wallis Mann–Whitney. Result Treatment dose 100 mg/kg BW significantly reduces edema, infiltration, malondialdedhyde, increase comparison without treatment. did reduce leukocyte, only decrease significantly.