[Cerebrospinal fluid biomarkers for the early diagnosis of Parkinson's disease].

摘要: In current medical practice, the diagnosis of Parkinson's disease remains essentially clinical. This practice determines that is done in an already advanced neuropathological stage disease. The aim this study to review validity cerebrospinal fluid protein biological markers early a-synuclein and DJ-1 proteins, due their role hereditary disease, have been most widely studied biomarkers. Nevertheless, they had divergent results mostly owing different processing, identification control laboratory techniques. new proteomic techniques, directed detection multiple undifferentiated proteins (eg. ceruloplasmin, chromogranin B, apoH), are promising. imperious as it a progressive neurodegenerative disorder causes extensive morbidity. Most scientific research focused on discovery neuroprotective drugs. Thus, definition biomarkers for highly relevant.