Effects of variable dose milrinone in patients with low cardiac output after cardiac surgery

摘要: We studied 99 adult patients after elective cardiac surgery who had low output (cardiac index 2 ) in spite of adequate filling pressure (pulmonary capillary wedge >8 mm Hg). Patients received milrinone by loading dose (50 μg/kg over a 10-minute period), followed continuous infusion either 0.375, 0.5, or 0.75 μg/kg/min (low-, middle-, and high-dose groups, respectively) given for minimum 12 hours. were allocated to each dosage group sequentially, not randomly. Hemodynamic measurements made before the at 15, 30, 45, 60 minutes, 3, 6, hours start therapy. Further 4 treatment was stopped. Milrinone therapy associated with rapid, well-sustained, highly significant increase all three groups ( p