Amrinone versus dobutamine in cardiac surgical patients with severe pulmonary hypertension after cardiopulmonary bypass: a prospective, randomized double-blinded trial.
作者： I. R. Jenkins , J. Dolman , J. P. O'Connor , D. M. Ansley
DOI: 10.1177/0310057X9702500306
关键词:
摘要: We compared the relative effects of dobutamine (5 micrograms/kg/min) and amrinone (1.0 mg/kg bolus followed by 10 on right left ventricular function pulmonary arterial pressures during weaning from cardiopulmonary bypass in patients with a mean preoperative pressure > 30 mmHg. Twenty scheduled for mitral valve replacement were studied prospective, randomized, double-blind trial. Patients receiving had greater increase cardiac index (CI) 1.38 (+/-0.95) litre/min/m2 at separation vs 0.69 (+/-0.63) group (P < 0.05). The also ejection fraction (0.15 +/- 0.08 versus an 0.04 0.11 those dobutamine; P 0.005). Amrinone produced larger decrease artery wedge 8.0 (+/-4.4) mmHg 0.75 (+/-6.6) separation; systolic diastolic reduced more group. There no differences heart rate, pressure, central venous stroke work between patient groups. In doses chosen, use to was associated reduction after severe hypertension.
sci-hub.se 参考文章(9)
Roger L. Royster, John F. Butterworth, Richard C. Prielipp, Gary P. Zaloga, Stephen G. Lawless, Beverly J. Spray, Neal D. Kon, Stephen L. Wallenhaupt, A. Robert Cordell, Combined inotropic effects of amrinone and epinephrine after cardiopulmonary bypass in humans. Anesthesia & Analgesia. ,vol. 77, pp. 662- 672 ,(1993) , 10.1213/00000539-199310000-00003
B. Keogh, R. Priddy, C. Morgan, C. Gillbe, Comparative study of the effects of enoximone and dobutamine in patients with impaired left ventricular function undergoing cardiac surgery. The Cardiology. ,vol. 77, pp. 58- 61 ,(1990) , 10.1159/000174673
A. PETRY, P. DÜTSCHKE, Effects of amrinone on left and right ventricular function in patients with impaired myocardial performance during general anaesthesia BJA: British Journal of Anaesthesia. ,vol. 72, pp. 567- 570 ,(1994) , 10.1093/BJA/72.5.567
Robert O. Feneck, Effects of variable dose milrinone in patients with low cardiac output after cardiac surgery American Heart Journal. ,vol. 121, pp. 1995- 1999 ,(1991) , 10.1016/0002-8703(91)90836-7
James M. Bailey, Jerrold H. Levy, H. Gary Rogers, Fania Szlam, Carl C. Hug, Pharmacokinetics of amrinone during cardiac surgery. Anesthesiology. ,vol. 75, pp. 961- 968 ,(1991) , 10.1097/00000542-199112000-00006
Davy C.H. Cheng, Buvanendran Asokumar, Takashi Nakagawa, Amrinone Therapy for Severe Pulmonary Hypertension and Biventricular Failure After Complicated Valvular Heart Surgery Chest. ,vol. 104, pp. 1618- 1620 ,(1993) , 10.1378/CHEST.104.5.1618
G.Michael Deeb, Steven F. Boiling, Todd P. Guynn, John M. Nicklas, Amrinone versus conventional therapy in pulmonary hypertensive patients awaiting cardiac transplantation The Annals of Thoracic Surgery. ,vol. 48, pp. 665- 669 ,(1989) , 10.1016/0003-4975(89)90785-6
John F. Butterworth, Roger L. Royster, Richard C. Prielipp, Stephen T. Lawless, Stephen L. Wallenhaupt, Amrinone in Cardiac Surgical Patients With Left-Ventricular Dysfunction: A Prospective, Randomized Placebo-controlled Trial Chest. ,vol. 104, pp. 1660- 1667 ,(1993) , 10.1378/CHEST.104.6.1660
Jean-Yves Dupuis, Richard Bondy, Charles Cattran, Howard J. Nathan, J. Earl Wynands, Amrinone and dobutamine as primary treatment of low cardiac output syndrome following coronary artery surgery: A comparison of their effects on hemodynamics and outcome Journal of Cardiothoracic and Vascular Anesthesia. ,vol. 6, pp. 542- 553 ,(1992) , 10.1016/1053-0770(92)90096-P