Amrinone and dobutamine as primary treatment of low cardiac output syndrome following coronary artery surgery: A comparison of their effects on hemodynamics and outcome

摘要: Abstract This study was undertaken in order to compare the effectiveness of amrinone and dobutamine as primary treatment a low cardiac output (CO) after coronary artery bypass graft (CABG) surgery. Thirty patients with preoperative left ventricular dysfunction participated this open-label randomized study. Patients were included if they failed separate from cardiopulmonary (CPB) without inotropic support or had index (CI) less than 2.4 L/min/m2 CPB regardless blood pressure, presence adequate filling pressures. The objectives achieve CI ≥ mean arterial pressure 70 mmHg. treated received 0.75 mg/kg followed by 10 μg/kg/min; when not achieved within five minutes, another given. an initial infusion 5 μg/kg/min increased stepwise 15 necessary. Eleven versus 6 predefined test drug alone (P = NS). Comparisons hemodynamics solely (n 7) 6) showed no significant differences between groups. incidence myocardial ischemia detected Holter monitor 36% 33% dobutamine. Two suffered fibrillation two supraventricular tachyarrhythmias (heart rate > 130/min) during alone, whereas arrhythmias occurred group Six (40%) postoperative infarction (MI) opposed none among 0.017). These results indicate that compares favorably CO CABG. Further larger number will be required determine lower Ml due drug.