Modulation of poly(ADP-ribosylation) in apoptotic cells.

作者: A Ivana Scovassi , Marc Diederich

DOI: 10.1016/J.BCP.2004.04.023

关键词:

摘要: Poly(ADP-ribosylation) is a post-translational modification of proteins playing crucial role in DNA repair, replication, transcription and cell death. In this paper, the main features process have been reviewed, focusing on best known poly(ADP-ribose) polymerizing enzyme, PARP-1, nick-sensor protein that uses b-NAD þ to form polymers ADP-ribose. The modulation poly(ADP-ribosylation) during apoptosis possible effects its inhibition metabolism are discussed.

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