Activation of DNA-degrading enzymes during apoptosis.

作者: AI Scovassi , A Torriglia

DOI: 10.4081/826

关键词: EnzymeCell biologyProteasesDNAProgrammed cell deathBiologyApoptosisBiochemistry

摘要: Cell death by apoptosis requires a precise plan of destruction DNA and proteins. In this paper, we review the current knowledge on different DNA-degrading enzymes which are activated in apoptotic cells. The activation DNases upstream proteases is also discussed.

参考文章(136)
A. Ivana Scovassi, Guy G. Poirier, Poly(ADP-ribosylation) and apoptosis. Molecular and Cellular Biochemistry. ,vol. 199, pp. 125- 137 ,(1999) , 10.1023/A:1006962716377
Jason E. Reynolds, Alan Eastman, Michael A. Barry, Etoposide-induced Apoptosis in Human HL-60 Cells Is Associated with Intracellular Acidification Cancer Research. ,vol. 53, pp. 2349- 2357 ,(1993)
M. K. T. Squier, J. J. Cohen, Calpain, an upstream regulator of thymocyte apoptosis. Journal of Immunology. ,vol. 158, pp. 3690- 3697 ,(1997)
Jay Parrish, Lily Li, Kristina Klotz, Duncan Ledwich, Xiaodong Wang, Ding Xue, Mitochondrial endonuclease G is important for apoptosis in C. elegans Nature. ,vol. 412, pp. 90- 94 ,(2001) , 10.1038/35083608
M.C. Peitsch, B. Polzar, H. Stephan, T. Crompton, H.R. MacDonald, H.G. Mannherz, J. Tschopp, Characterization of the endogenous deoxyribonuclease involved in nuclear DNA degradation during apoptosis (programmed cell death). The EMBO Journal. ,vol. 12, pp. 371- 377 ,(1993) , 10.1002/J.1460-2075.1993.TB05666.X
Craig W. Hendrix, Pierre A. Henkart, Apurva Sarin, Gene M. Shearer, Mario Clerici, Stephen P. Blatt, Inhibition of activation-induced programmed cell death and restoration of defective immune responses of HIV+ donors by cysteine protease inhibitors. Journal of Immunology. ,vol. 153, pp. 862- 872 ,(1994)
Pierre A. Henkart, Apurva Sarin, Elias K. Haddad, Caspase Dependence of Target Cell Damage Induced by Cytotoxic Lymphocytes Journal of Immunology. ,vol. 161, pp. 2810- 2816 ,(1998)
A.H. Wyllie, J.F.R. Kerr, A.R. Currie, Cell death : the significance of apoptosis International Review of Cytology-a Survey of Cell Biology. ,vol. 68, pp. 251- 306 ,(1980) , 10.1016/S0074-7696(08)62312-8