Biomarkers of Lung Injury in Cardiothoracic Surgery

作者: Gerwin Erik Engels , Willem van Oeveren

DOI: 10.1155/2015/472360

关键词:

摘要: Diagnosis of pulmonary dysfunction is currently almost entirely based on a vast series physiological changes, but comprehensive research focused determining biomarkers for early diagnosis dysfunction. Here we discuss the use lung injury in cardiothoracic surgery and their ability to detect subtle perioperative period. Degranulation products neutrophils are often used as biomarker since they have detrimental effects tissue by themselves. However, these substances not specific. Lung epithelium specific proteins offer more specificity slowly find way into clinical studies.

参考文章(101)
G. R. Bernard, , A. Artigas, K. L. Brigham, J. Carlet, K. Falke, L. Hudson, M. Lamy, J. R. LeGall, A. Morris, R. Spragg, Report of the American-European consensus conference on ARDS: definitions, mechanisms, relevant outcomes and clinical trial coordination. The Consensus Committee. Intensive Care Medicine. ,vol. 20, pp. 225- 232 ,(1994) , 10.1007/BF01704707
T E Weaver, J A Whitsett, Function and regulation of expression of pulmonary surfactant-associated proteins. Biochemical Journal. ,vol. 273, pp. 249- 264 ,(1991) , 10.1042/BJ2730249
Joshua M Diamond, Steven M Kawut, David J Lederer, Vivek N Ahya, Benjamin Kohl, Joshua Sonett, Scott M Palmer, Maria Crespo, Keith Wille, VN Lama, Pali D Shah, Jonathan Orens, Sangeeta Bhorade, Ann Weinacker, Ejigayehu Demissie, Scarlett Bellamy, Jason D Christie, Lorraine B Ware, Lung Transplant Outcomes Group, None, Elevated plasma Clara cell secretory protein concentration is associated with high-grade primary graft dysfunction American Journal of Transplantation. ,vol. 11, pp. 561- 567 ,(2011) , 10.1111/J.1600-6143.2010.03431.X
R. J. Shah, N. Wickersham, D. J. Lederer, S. M. Palmer, E. Cantu, J. M. Diamond, S. M. Kawut, V. N. Lama, S. Bhorade, M. Crespo, E. Demissie, J. Sonett, K. Wille, J. Orens, A. Weinacker, P. Shah, S. Arcasoy, D. S. Wilkes, J. D. Christie, L. B. Ware, , Preoperative Plasma Club (Clara) Cell Secretory Protein Levels Are Associated With Primary Graft Dysfunction After Lung Transplantation American Journal of Transplantation. ,vol. 14, pp. 446- 452 ,(2014) , 10.1111/AJT.12541
Madoka Shirasawa, Naoyuki Fujiwara, Susumu Hirabayashi, Hideki Ohno, Junko Iida, Koshi Makita, Yutaka Hata, Receptor for advanced glycation end-products is a marker of type I lung alveolar cells. Genes to Cells. ,vol. 9, pp. 165- 174 ,(2004) , 10.1111/J.1356-9597.2004.00712.X
R. J. Shah, S. L. Bellamy, J. C. Lee, E. Cantu, J. M. Diamond, N. Mangalmurti, S. M. Kawut, L. B. Ware, J. D. Christie, Early plasma soluble receptor for advanced glycation end-product levels are associated with bronchiolitis obliterans syndrome. American Journal of Transplantation. ,vol. 13, pp. 754- 759 ,(2013) , 10.1111/AJT.12062
Douglas F. Gibbs, Thomas P. Shanley, Roscoe L. Warner, Hedwig S. Murphy, James Varani, Kent J. Johnson, Role of Matrix Metalloproteinases in Models of Macrophage-Dependent Acute Lung Injury Evidence for Alveolar Macrophage as Source of Proteinases American Journal of Respiratory Cell and Molecular Biology. ,vol. 20, pp. 1145- 1154 ,(1999) , 10.1165/AJRCMB.20.6.3482
Hedy H. Ginzberg, Vera Cherapanov, Qin Dong, Andre Cantin, Christopher A. G. McCulloch, Patrick T. Shannon, Gregory P. Downey, Neutrophil-mediated epithelial injury during transmigration: role of elastase American Journal of Physiology-gastrointestinal and Liver Physiology. ,vol. 281, ,(2001) , 10.1152/AJPGI.2001.281.3.G705