From a fish tank injury to hospital haemodialysis: the serious consequences of drug interactions

摘要: We present the case of a 68-year-old man admitted to hospital with severe acute kidney injury secondary statin-induced rhabdomyolysis. Five weeks previously, patient started course clarithromycin for infection finger wound Mycobacterium marinum. His current medications included simvastatin, which he continued along clarithromycin. The severity necessitated initial continuous venovenous haemofiltration followed by 12 haemodialysis sessions before spontaneous improvement in renal function occurred. Statins are widely prescribed and we report this encourage increased vigilance avoiding drug interactions known increase risk myopathy, including macrolide antibiotics, calcium channel antagonists amiodarone. authors would also like highlight recent guidance on atorvastatin as statin choice patients chronic disease, need dose adjustment those an estimated glomerular filtration rate less than 30 mLs/min/1.73 m².