The clinical significance of statins-macrolides interaction: comprehensive review of in vivo studies, case reports, and population studies.

作者: Abdallah Abu Mellal , Nadia Hussain , Amira Said

DOI: 10.2147/TCRM.S214938

关键词:

摘要: The objectives of this article were to review the mechanism and clinical significance statins-macrolides interaction, determine which combination has highest risk for identify key patients' factors interaction in relation development muscle toxicity. A literature was conducted PubMed Embase (1946 December 2018) using combined terms: statins - as group individual agents, macrolides drug toxicity, rhabdomyolysis, CYP3A4 inhibitors, OAT1B with forward backward citation tracking. Relevant English language vivo studies healthy volunteers, case reports, population included. between depends on type statin macrolide used. is due macrolides' inhibition isoenzyme transporter causing increased exposure statins. correlation statin's toxicity could not be established, unless patient had other such advanced age, cardiovascular diseases, renal impairment, diabetes, concomitant use inhibitors. Simvastatin, lovastatin, lesser extent atorvastatin are most affected by interaction. Rosuvastatin, fluvastatin, pravastatin significantly Telithromycin, clarithromycin, erythromycin "offending" macrolides, while azithromycin appears safe This presented a clear description real practice. Also, it provided health care professionals suggestions recommendations how overcome In conclusion, understanding different characteristics each macrolide, well factors, will enable providers utilize both groups effectively without compromising safety.

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