Antitussive, anti-pyretic and toxicological evaluation of Ma-Xing-Gan-Shi-Tang in rodents

摘要: Ma-Xing-Gan-Shi-Tang (abbreviated as MXGST), an important Chinese herbal prescribed for cough, bronchial inflammation and fever from pneumonia, consists of four medicinal herbs, including Ephedrae herb, Semen Pruni Armeniacae, licorice Gypsum. These components, especially possess antitussive activities, but they have severe adverse effects. The pharmacological activities MXGST extract in clinical use were investigated with citric acid-induced acetylcholine/histamine-induced contraction lipopolysaccharide (LPS)-induced rodents. subacute toxicology was evaluated after a 28-day repeated oral administration rats. Each gram contained 60 ± 8 μg ephedrine, 480 ± 40 μg glycyrrhizic acid 440 ± 8 μg amygdalin according to high performance liquid chromatography photodiode array detector. produced pronounced, dose-dependent effects guinea pigs reduced hyperthermic syndrome induced by LPS blocked the acetylcholine/histamine. Oral 28 days did not cause any hematological, biochemical or histological changes is safer, more effective prescription anti-pyretic mechanism related partially relaxing smooth muscle blocking acetylcholinergic histaminergic receptors.