Pharmacological evaluation for anti-asthmatic and anti-inflammatory potential of Woodfordia fruticosa flower extracts.
作者： Mahavir Hiralal Ghante , Kishore P. Bhusari , Nandkishore J. Duragkar , Nitin B. Ghiware
DOI: 10.3109/13880209.2013.869232
关键词: Anti-inflammatory 、 Ethyl acetate 、 Woodfordia fruticosa 、 Traditional medicine 、 Histamine 、 Botany 、 In vivo 、 Lythraceae 、 Chemistry 、 Degranulation 、 Guinea pig
摘要: AbstractContext: Woodfordia fruticosa Kurz. (Lythraceae) flowers are ethnopharmacologically acclaimed in the Indian medicinal system to treat asthma.Objective: To evaluate W. flower extracts for anti-asthmatic effect.Materials and methods: Ethyl acetate, acetone, methanol, hydro-alcohol of were obtained successively standardized. Ability stabilize free radicals compound-48/80-induced mast cell degranulation was evaluated. In vitro anti-inflammatory potential at 100 200 µg/ml by membrane stabilization vivo inhibition rat paw edema up 5 h (100 200 mg/ml; p.o.) bronchorelaxant effect examined against histamine- acetylcholine (1 µg/ml; independently)-induced guinea pig tracheal contraction. Extracts evaluated bronchoprotection (in vivo) ability 0.1% 2% acetylcholine-induced bronchospasm pigs p.o.Results: Standardizat...
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