Woodfruticosin (woodfordin C), a new inhibitor of DNA topoisomerase II: Experimental antitumor activity
作者： Kuramochi-Motegi Akiko , Kuramochi Hiroshi , Kobayashi Fumiko , Ekimoto Hisao , Takahashi Katsutoshi
DOI: 10.1016/0006-2952(92)90098-4
关键词: Biological activity 、 In vitro 、 DNA 、 Enzyme inhibitor 、 Biology 、 Etoposide 、 Woodfordia fruticosa 、 In vivo 、 DNA synthesis 、 Molecular biology 、 Biochemistry
摘要: Abstract Woodfruticosin (woodfordin C) (WFC), a new inhibitor of DNA topoisomerase II (topo-II), was isolated from methanol extract Woodfordia fruticosa Kurz (Lythraceae) and studied for in vitro vivo antitumor activities comparison with Adriamycin ® (ADR) etoposide (ETP), well known inhibitors topo-II. The inhibitory activity against topo-II shown by WFC much stronger than that ETP or ADR. inhibited strongly intracellular synthesis but not RNA protein synthesis. On the other hand, had weaker growth various human tumor cells ADR, it showed remarkable PC-1 moderate MKN45 KB cells. Furthermore, s.c. inoculated colon38. These results indicate mechanism which exhibits may be through inhibition
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sci-hub.se 参考文章(16)
J.-B. Le Pecq, Y. Pommier, K. W. Kohn, C. Esnault, M. R. Mattern, B. P. Roques, J. Markovits, Effects of the Bifunctional Antitumor Intercalator Ditercalinium on DNA in Mouse Leukemia L1210 Cells and DNA Topoisomerase II Cancer Research. ,vol. 46, pp. 5821- 5826 ,(1986)
K G Miller, L F Liu, P T Englund, A homogeneous type II DNA topoisomerase from HeLa cell nuclei. Journal of Biological Chemistry. ,vol. 256, pp. 9334- 9339 ,(1981) , 10.1016/S0021-9258(19)52552-2
Robert P. Hertzberg, Michael R. Mattern, Joan O'Leary Bartu, Shau-Ming Mong, Glenn A. Hofmann, Randall K. Johnson, Christopher K. Mirabelli, Fred H. Drake, In Vitro and Intracellular Inhibition of Topoisomerase II by the Antitumor Agent Merbarone Cancer Research. ,vol. 49, pp. 2578- 2583 ,(1989)
Yves Pommier, Veronique Pierson, Pierre Gros, Alain Pierre, Production of Protein-associated DNA Breaks by 10-[Diethylaminopropylamino]-6-methyl-5H-pyrido[3′,4′:4,5]pyrrolo[2,3-g]isoquinoline in Cultured L1210 Cells and in Isolated Nuclei: Comparison with Other Topoisomerase II Inhibitors Cancer Research. ,vol. 48, pp. 1404- 1409 ,(1988)
P T Englund, Free minicircles of kinetoplast DNA in Crithidia fasciculata. Journal of Biological Chemistry. ,vol. 254, pp. 4895- 4900 ,(1979) , 10.1016/S0021-9258(17)30096-0
Yves Pommier, Joseph M. Covey, Donna Kerrigan, Judith Markovits, Richard Pham, DNA unwinding and inhibition of mouse leukemia L1210 DNA topoisomerase I by intercalators Nucleic Acids Research. ,vol. 15, pp. 6713- 6731 ,(1987) , 10.1093/NAR/15.16.6713
Shigetoshi Kadota, Yasushi Takamori, Tohru Kikuchi, Akiko Motegi, Hisao Ekimotob, Woodfruticosin, an inhibitor of DNA topoisomerase II from kurz Tetrahedron Letters. ,vol. 31, pp. 393- 396 ,(1990) , 10.1016/S0040-4039(00)94563-5
K. Tewey, T. Rowe, L Yang, B. Halligan, L. Liu, Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II Science. ,vol. 226, pp. 466- 468 ,(1984) , 10.1126/SCIENCE.6093249
Theodore J. Boritzki, Tammy S. Wolfard, Judith A. Besserer, Robert C. Jackson, David W. Fry, Inhibition of type II topoisomerase by fostriecin. Biochemical Pharmacology. ,vol. 37, pp. 4063- 4068 ,(1988) , 10.1016/0006-2952(88)90096-2
Akira Okura, Hiroharu Arakawa, Hirofumi Oka, Tomoko Yoshinari, Yoshiaki Monden, Effect of genistein on topoisomerase activity and on the growth of [Val 12]Ha-ras-transformed NIH 3T3 cells. Biochemical and Biophysical Research Communications. ,vol. 157, pp. 183- 189 ,(1988) , 10.1016/S0006-291X(88)80030-5