Relation of a Common Mutation in Methylenetetrahydrofolate Reductase to Plasma Homocysteine and Early Onset Coronary Artery Disease

摘要: Objective: In the presence of low serum folate, mutant 5,10-methylenetetrahydrofolate reductase (MTHFR+ [A223V/C677T]) in homozygous state (+/+), may predispose to higher plasma homocysteine (tHct) levels and coronary artery disease (CAD). To determine impact this relationship on predisposition early-onset CAD, we examined prevalence mutation tHct patients with CAD compared them manifesting later life. Methods: Three hundred history acute myocardial infarction or angina pectoris angiographically documented were studied. Patients consisted two groups: group 1 (G1 = 150 patients) presenting these findings under age 50; while 2 (G2 150) presented for first time over 65 years. Prevalence MTHFR+ was assessed by molecular analysis, folate measured. An association +/+ genotype early onset could lead its younger group. Results: There no significant difference frequency (+/+) between groups (G1: 11.3% vs. G2: 11.3%). However, both had when below mean value p < 0.0001 0.01). Conclusion: The MTHFR not found be a determining factor CAD. Higher values obtained older group, which is expected because other studies have shown that increase age. A relation status yielding high those genotype. As seen groups, although lesser extent G2, it does explain underlying cause