Genetic Covariance Between γ-Glutamyl Transpeptidase and Fatty Liver Risk Factors: Role of β2-Adrenergic Receptor Genetic Variation in Twins

摘要: Background & Aims Plasma levels of γ-glutamyl transpeptidase (GGT) are associated with risk factors for nonalcoholic fatty liver disease (NAFLD), such as dyslipidemia, insulin resistance (IR), and hypertension. Limited data exist on whether there is genetic covariance between plasma GGT NAFLD factors. Variants β2-adrenergic receptor gene ( ADRB2 ) have been IR, hypertension, but its effect secretion not known. We estimated the heritability using a twin-study design examined levels, low-density lipoproteins triglycerides, variants. Methods studied phenotypes 362 twins; heritabilities increased activity were by variance-component methodology. genotype associations generalized estimating equations to account intra-twinship correlations. Results was heritable at 49% ± 8% twin cohort had significant IR; insulin, triglyceride, uric acid levels; diastolic blood pressure. In equation models, most common haplotype significantly activity. Five single nucleotide polymorphisms in GGT; haplotypes displayed pleiotropic effects triglyceride levels. Conclusions study, shared codetermination traits metabolic syndrome. The indicating linked pathways (eg, adrenergic) susceptibility