Molecular design, chemical synthesis, and biological evaluation of '4-1' pentacyclic aryl/heteroaryl-imidazonaphthalimides.
作者： Feng Li , Jingnan Cui , Lianying Guo , Xuhong Qian , Weimin Ren
DOI: 10.1016/J.BMC.2007.05.032
关键词:
摘要: A novel series of '4-1' pentacyclic naphthalimides, where the chromophore consists a naphthalimide moiety, fused to an imidazole ring containing unfused aryl or heteroaryl ring, were synthesized and evaluated for in vitro antitumor activity. In general, new derivatives showed improved cytotoxic activity over amonafide. DNA binding experiments supported that this class compounds behaves as effective DNA-intercalating agents.
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