A novel prostate cancer susceptibility locus at 19q13
作者： Fang-Chi Hsu , Jielin Sun , Fredrik Wiklund , Sarah D. Isaacs , Kathleen E. Wiley
DOI: 10.1158/0008-5472.CAN-08-3347
关键词:
摘要: A two-stage genome-wide association study (GWAS) of the Cancer Genetic Markers Susceptibility (CGEMS) initiative identified single nucleotide polymorphisms (SNP) in 150 regions across genome that may be associated with prostate cancer (PCa) risk. We filtered these results to identify 43 independent SNPs where frequency risk allele was consistently higher cases than controls each five CGEMS populations. Genotype information for 22 obtained either directly by genotyping or indirectly imputation our PCa GWAS 500 and selected from a population-based case-control Sweden [Cancer Prostate (CAPS)]. Two were significantly (P<0.05). then genotyped two remaining (n=2,393) (n=1,222) CAPS found rs887391 at 19q13 highly (P=9.4 x 10(-4)). similar trend this SNP Johns Hopkins Hospital (JHH), albeit result not statistically significant. Altogether, among seven populations examined, an overall P=3.2 10(-7) combined allelic test. fine-mapping 110-kb region JHH revealed most strongly region. Additional confirmation studies are warranted.
aacrjournals.org
elsevier.com
cabdirect.org
sci-hub.se 参考文章(18)
S. Lilly Zheng, Jielin Sun, Fredrik Wiklund, Shelly Smith, Pär Stattin, Ge Li, Hans-Olov Adami, Fang-Chi Hsu, Yi Zhu, Katarina Bälter, A. Karim Kader, Aubrey R. Turner, Wennuan Liu, Eugene R. Bleecker, Deborah A. Meyers, David Duggan, John D. Carpten, Bao-Li Chang, William B. Isaacs, Jianfeng Xu, Henrik Grönberg, Cumulative Association of Five Genetic Variants with Prostate Cancer The New England Journal of Medicine. ,vol. 358, pp. 910- 919 ,(2008) , 10.1056/NEJMOA075819
Rosalind A Eeles, , Zsofia Kote-Jarai, Graham G Giles, Ali Amin Al Olama, Michelle Guy, Sarah K Jugurnauth, Shani Mulholland, Daniel A Leongamornlert, Stephen M Edwards, Jonathan Morrison, Helen I Field, Melissa C Southey, Gianluca Severi, Jenny L Donovan, Freddie C Hamdy, David P Dearnaley, Kenneth R Muir, Charmaine Smith, Melisa Bagnato, Audrey T Ardern-Jones, Amanda L Hall, Lynne T O'Brien, Beatrice N Gehr-Swain, Rosemary A Wilkinson, Angie Cox, Sarah Lewis, Paul M Brown, Sameer G Jhavar, Malgorzata Tymrakiewicz, Artitaya Lophatananon, Sarah L Bryant, Alan Horwich, Robert A Huddart, Vincent S Khoo, Christopher C Parker, Christopher J Woodhouse, Alan Thompson, Tim Christmas, Chris Ogden, Cyril Fisher, Charles Jamieson, Colin S Cooper, Dallas R English, John L Hopper, David E Neal, Douglas F Easton, , , Multiple newly identified loci associated with prostate cancer susceptibility. Nature Genetics. ,vol. 40, pp. 316- 321 ,(2008) , 10.1038/NG.90
M. L. Freedman, C. A. Haiman, N. Patterson, G. J. McDonald, A. Tandon, A. Waliszewska, K. Penney, R. G. Steen, K. Ardlie, E. M. John, I. Oakley-Girvan, A. S. Whittemore, K. A. Cooney, S. A. Ingles, D. Altshuler, B. E. Henderson, D. Reich, Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men Proceedings of the National Academy of Sciences of the United States of America. ,vol. 103, pp. 14068- 14073 ,(2006) , 10.1073/PNAS.0605832103
Robert F. Hoedemaeker, Andr� N. Vis, Theodorus H. Van Der Kwast, Staging prostate cancer. Microscopy Research and Technique. ,vol. 51, pp. 423- 429 ,(2000) , 10.1002/1097-0029(20001201)51:5<423::AID-JEMT4>3.0.CO;2-4
Christopher A Haiman, Nick Patterson, Matthew L Freedman, Simon R Myers, Malcolm C Pike, Alicja Waliszewska, Julie Neubauer, Arti Tandon, Christine Schirmer, Gavin J McDonald, Steven C Greenway, Daniel O Stram, Loic Le Marchand, Laurence N Kolonel, Melissa Frasco, David Wong, Loreall C Pooler, Kristin Ardlie, Ingrid Oakley-Girvan, Alice S Whittemore, Kathleen A Cooney, Esther M John, Sue A Ingles, David Altshuler, Brian E Henderson, David Reich, Multiple regions within 8q24 independently affect risk for prostate cancer. Nature Genetics. ,vol. 39, pp. 638- 644 ,(2007) , 10.1038/NG2015
Gilles Thomas, Kevin B Jacobs, Meredith Yeager, Peter Kraft, Sholom Wacholder, Nick Orr, Kai Yu, Nilanjan Chatterjee, Robert Welch, Amy Hutchinson, Andrew Crenshaw, Geraldine Cancel-Tassin, Brian J Staats, Zhaoming Wang, Jesus Gonzalez-Bosquet, Jun Fang, Xiang Deng, Sonja I Berndt, Eugenia E Calle, Heather Spencer Feigelson, Michael J Thun, Carmen Rodriguez, Demetrius Albanes, Jarmo Virtamo, Stephanie Weinstein, Fredrick R Schumacher, Edward Giovannucci, Walter C Willett, Olivier Cussenot, Antoine Valeri, Gerald L Andriole, E David Crawford, Margaret Tucker, Daniela S Gerhard, Joseph F Fraumeni, Robert Hoover, Richard B Hayes, David J Hunter, Stephen J Chanock, Multiple loci identified in a genome-wide association study of prostate cancer Nature Genetics. ,vol. 40, pp. 310- 315 ,(2008) , 10.1038/NG.91
Julius Gudmundsson, Patrick Sulem, Andrei Manolescu, Laufey T Amundadottir, Daniel Gudbjartsson, Agnar Helgason, Thorunn Rafnar, Jon T Bergthorsson, Bjarni A Agnarsson, Adam Baker, Asgeir Sigurdsson, Kristrun R Benediktsdottir, Margret Jakobsdottir, Jianfeng Xu, Thorarinn Blondal, Jelena Kostic, Jielin Sun, Shyamali Ghosh, Simon N Stacey, Magali Mouy, Jona Saemundsdottir, Valgerdur M Backman, Kristleifur Kristjansson, Alejandro Tres, Alan W Partin, Marjo T Albers-Akkers, Javier Godino-Ivan Marcos, Patrick C Walsh, Dorine W Swinkels, Sebastian Navarrete, Sarah D Isaacs, Katja K Aben, Theresa Graif, John Cashy, Manuel Ruiz-Echarri, Kathleen E Wiley, Brian K Suarez, J Alfred Witjes, Mike Frigge, Carole Ober, Eirikur Jonsson, Gudmundur V Einarsson, Jose I Mayordomo, Lambertus A Kiemeney, William B Isaacs, William J Catalona, Rosa B Barkardottir, Jeffrey R Gulcher, Unnur Thorsteinsdottir, Augustine Kong, Kari Stefansson, Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24. Nature Genetics. ,vol. 39, pp. 631- 637 ,(2007) , 10.1038/NG1999
Jonathan I Epstein, William C Allsbrook Jr, Mahul B Amin, Lars L Egevad, ISUP Grading Committee, None, The 2005 International Society of Urological Pathology (ISUP) consensus conference on Gleason grading of prostatic carcinoma The American Journal of Surgical Pathology. ,vol. 29, pp. 1228- 1242 ,(2005) , 10.1097/01.PAS.0000173646.99337.B1
Jiyoung Ahn, Sonja I Berndt, Sholom Wacholder, Peter Kraft, Adam S Kibel, Meredith Yeager, Demetrius Albanes, Edward Giovannucci, Meir J Stampfer, Jarmo Virtamo, Michael J Thun, Heather Spencer Feigelson, Geraldine Cancel-Tassin, Olivier Cussenot, Gilles Thomas, David J Hunter, Joseph F Fraumeni, Robert N Hoover, Stephen J Chanock, Richard B Hayes, Variation in KLK genes, prostate-specific antigen and risk of prostate cancer Nature Genetics. ,vol. 40, pp. 1032- 1034 ,(2008) , 10.1038/NG0908-1032
S. D. Isaacs, Y. Cheng, G. Li, J. Sun, B.-L. Chang, L. Marovich, K. E. Wiley, K. Balter, P. Stattin, H.-O. Adami, M. Gielzak, G. Yan, J. Sauvageot, W. Liu, J. W. Kim, E. R. Bleecker, D. A. Meyers, B. J. Trock, A. W. Partin, P. C. Walsh, W. B. Isaacs, H. Gronberg, J. Xu, J. D. Carpten, D. Duggan, S. L. Zheng, M. Knowlton, D. Benitez, L. Dimitrov, F. Wiklund, C. Robbins, Two Genome-wide Association Studies of Aggressive Prostate Cancer Implicate Putative Prostate Tumor Suppressor Gene DAB2IP Journal of the National Cancer Institute. ,vol. 99, pp. 1836- 1844 ,(2007) , 10.1093/JNCI/DJM250