Accumulating Evidence Suggests that Parkinson’s Disease Is a Prion-Like Disorder

摘要: Parkinson’s disease is the second most prevalent neurodegenerative disease, affecting hundreds of thousands people per year. Although etiology disorder unclear, recent studies have shown key involvement alpha-synuclein in PD. Lewy bodies and neurites, hallmarks contain mostly aggregated develop progressively brain a predictable spatial pattern. It has been proposed that misfolded form transfers between neighboring cells prion-like fashion, acts like seed, promotes protein aggregation those cells, contributing to progression pathology from one region another. Here, we review first known mechanisms cell-to-cell transfer. We will then discuss nature seed process and, finally, what missing literature understand spread regions.