Role of post-translational modifications in modulating the structure, function and toxicity of alpha-synuclein: implications for Parkinson's disease pathogenesis and therapies.
作者： Abid Oueslati , Margot Fournier , Hilal A. Lashuel
DOI: 10.1016/S0079-6123(10)83007-9
关键词:
摘要: … disease-associated α-syn post-translational modifications … the major disease-associated post-translational modifications (… of the effect of these modifications on α-syn aggregation and …
elsevier.com
sci-hub.se 参考文章(121)
Naoto Sugeno, Atsushi Takeda, Takafumi Hasegawa, Michiko Kobayashi, Akio Kikuchi, Fumiaki Mori, Koichi Wakabayashi, Yasuto Itoyama, Serine 129 Phosphorylation of α-Synuclein Induces Unfolded Protein Response-mediated Cell Death Journal of Biological Chemistry. ,vol. 283, pp. 23179- 23188 ,(2008) , 10.1074/JBC.M802223200
E. Liani, A. Eyal, E. Avraham, R. Shemer, R. Szargel, D. Berg, A. Bornemann, O. Riess, C. A. Ross, R. Rott, S. Engelender, Ubiquitylation of synphilin-1 and α-synuclein by SIAH and its presence in cellular inclusions and Lewy bodies imply a role in Parkinson's disease Proceedings of the National Academy of Sciences of the United States of America. ,vol. 101, pp. 5500- 5505 ,(2004) , 10.1073/PNAS.0401081101
M. Frasier, M. Walzer, L. McCarthy, D. Magnuson, J.M. Lee, C. Haas, P. Kahle, B. Wolozin, Tau phosphorylation increases in symptomatic mice overexpressing A30P α-synuclein Experimental Neurology. ,vol. 192, pp. 274- 287 ,(2005) , 10.1016/J.EXPNEUROL.2004.07.016
Mathijs Baens, Heidi Noels, Vicky Broeckx, Sofie Hagens, Sabine Fevery, An D. Billiau, Hugo Vankelecom, Peter Marynen, The dark side of EGFP: defective polyubiquitination. PLOS ONE. ,vol. 1, ,(2006) , 10.1371/JOURNAL.PONE.0000054
Melinda A. McFarland, Christopher E. Ellis, Sanford P. Markey, Robert L. Nussbaum, Proteomics Analysis Identifies Phosphorylation-dependent α-Synuclein Protein Interactions Molecular & Cellular Proteomics. ,vol. 7, pp. 2123- 2137 ,(2008) , 10.1074/MCP.M800116-MCP200
Dmitry Cherny, Wolfgang Hoyer, Vinod Subramaniam, Thomas M. Jovin, Double-stranded DNA stimulates the fibrillation of α-synuclein in vitro and is associated with the mature fibrils: An electron microscopy study Journal of Molecular Biology. ,vol. 344, pp. 929- 938 ,(2004) , 10.1016/J.JMB.2004.09.096
Nikolaus R. McFarland, Zhanyun Fan, Kui Xu, Michael A. Schwarzschild, Mel B. Feany, Bradley T. Hyman, Pamela J. McLean, α-Synuclein S129 Phosphorylation Mutants Do Not Alter Nigrostriatal Toxicity in a Rat Model of Parkinson Disease Journal of Neuropathology and Experimental Neurology. ,vol. 68, pp. 515- 524 ,(2009) , 10.1097/NEN.0B013E3181A24B53
Ayse Ulusoy, Gurdal Sahin, Tomas Björklund, Patrick Aebischer, Deniz Kirik, Dose Optimization for Long-term rAAV-mediated RNA Interference in the Nigrostriatal Projection Neurons. Molecular Therapy. ,vol. 17, pp. 1574- 1584 ,(2009) , 10.1038/MT.2009.142
Rina Bandopadhyay, Ann E. Kingsbury, Miratul M. Muqit, Kirsten Harvey, Andrew R. Reid, Linda Kilford, Simone Engelender, Michael G. Schlossmacher, Nicholas W. Wood, David S. Latchman, Robert J. Harvey, Andrew J. Lees, Synphilin-1 and parkin show overlapping expression patterns in human brain and form aggresomes in response to proteasomal inhibition. Neurobiology of Disease. ,vol. 20, pp. 401- 411 ,(2005) , 10.1016/J.NBD.2005.03.021
S. Kuzuhara, H. Mori, N. Izumiyama, M. Yoshimura, Y. Ihara, Lewy bodies are ubiquitinated. A light and electron microscopic immunocytochemical study. Acta Neuropathologica. ,vol. 75, pp. 345- 353 ,(1988) , 10.1007/BF00687787