Thin-layer chromatographic mobility of diastereoisomers

摘要: Abstract Conditions were determined for the chromatographic separation of diastereoisomeric compounds, viz. derivatives α-hydroxy-β-(indolyl-3)-butyric acids and β-methyltryptophans, in a thin sorbent layer. For majority investigated mobility A diastereoisomers (αRβS/αSβR configuration) is higher than that B diastereoisomer (αRβR/αSβS configuration). Sorption isotherms studied certain pairs sorption forces shown to be decisive factor process separating isomers. Possible conformations are considered supposition put forward greater sorptivity one isomer compared with other by steric accessibility polar groups this preferable conformation adsorbed state. suggestion made concerning molecules state on basis data derived comparative diastereoisomers.