p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage
作者： K F Macleod , N Sherry , G Hannon , D Beach , T Tokino
DOI: 10.1101/GAD.9.8.935
关键词:
摘要: Expression of p21 has been shown to be up-regulated by the p53 tumor suppressor gene in vitro response DNA-damaging agents. However, expression can regulated independently p53, and here we show that various tissues during development adult mouse occurs absence function. most tested did require for induction following exposure whole animal gamma irradiation. These results normal tissue high levels is not dependent on confirm agents does p53. expressed upon differentiation p53-deficient murine erythroleukemia (MEL) cells, kinetics this system suggest it may involved growth arrest precedes terminal differentiation. The fibroblasts serum restimulation but differ between wild-type mutant cells. message superinducible cycloheximide increases mRNA are reflected changes protein levels. also appears at post-transcriptional level because moderate expression, MEL cells fibroblasts, followed large Regulation promoter depends two critical p53-binding sites located 1.95 2.85 kb upstream from transcriptional initiation site. sequences mediating responsiveness map a region containing proximal play role DNA damage. Moreover, several situations including development, stimulation, cellular
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