Detection of Chemical Carcinogens by Unscheduled DNA Synthesis in Rat Liver Primary Cell Cultures

摘要: Unscheduled DNA synthesis was observed in primary rat liver cell cultures treated with members of five different classes chemical procarcinogens requiring enzymatic activation as well a direct-acting carcinogen. In total, ten carcinogens and one related analog not commonly accepted carcinogenic were active, while weak carcinogen four noncarcinogens inactive. The production unscheduled by this spectrum indicates that these have substantially retained the metabolic capability for activating diverse procarcinogens. Thus, such may be useful detecting ability chemicals to interact and, thereby, assigning them priority consideration potential cancer-causing agents.