Role of Ets Proteins in Development, Differentiation, and Function of T-Cell Subsets

摘要: Through positive selection, double-positive cells in the thymus differentiate into CD4(+) or CD8(+) T single-positive that subsequently develop different types of effective cells, such as T-helper and cytotoxic lymphocyte play distinctive roles immune system. Development, differentiation, function thymocytes are controlled by a multitude secreted intracellular factors, ranging from cytokine signaling modules to transcription factors epigenetic modifiers. Members E26 transformation specific (Ets) family particular, potent regulators these T-cell processes. In this review, we summarize discuss functions underlying mechanisms Ets members have been characterized involved Ongoing research is expected identify practical applications for novel therapeutic targets inflammation-related diseases.