AID, p53 and MLH1 expression in early gastric neoplasms and the correlation with the background mucosa
作者： SOICHIRO KAWATA , KAZUO YASHIMA , SOHEI YAMAMOTO , SHUJI SASAKI , YOHEI TAKEDA
DOI: 10.3892/OL.2015.3342
关键词:
摘要: A number of tumor-associated genes have been associated with gastric cancer development. The present study evaluated differences in protein expression and phenotype among early neoplasms, correlated these data those the background mucosa. activation-induced cytidine deaminase (AID), p53 MLH1 151 neoplasms [22 adenomas, 92 intramucosal carcinomas (MCs), 37 submucosal (SMCs)] was examined immunohistochemically compared that corresponding mucosal condition. cellular phenotypes intestinal metaplasia were also determined. Aberrant AID, detected 36.4, 0 0% 35.9, 32.6 16.3% MCs, 56.8, 62.2 21.6% SMCs, respectively. frequency aberrant AID SMCs significantly increased MCs (AID, P<0.05; p53, P<0.01). overexpression (P<0.01), but not adenomas or MCs. In addition, severity mononuclear cell activity non-cancerous mucosa adjacent to tumor (P<0.05), particularly SMC cases. percentage (34.8%) (24.3%) higher (18.2%). These results indicated a may be important for carcinogenesis, chronic inflammation are progression.
sci-hub.se 参考文章(40)
M J Baek, H Kang, S E Kim, J H Park, J S Lee, Y-K Paik, H Kim, Expression of hMLH1 is inactivated in the gastric adenomas with enhanced microsatellite instability British Journal of Cancer. ,vol. 85, pp. 1147- 1152 ,(2001) , 10.1054/BJOC.2001.2051
Sipponen P, Kimura K, Intestinal metaplasia, atrophic gastritis and stomach cancer: trends over time. European Journal of Gastroenterology & Hepatology. ,(1994)
K Takagi, K Nakamura, H Sugano, Carcinoma of the stomach in incipient phase: its histogenesis and histological appearances. Gann (Jpn J Cancer Res). ,vol. 59, pp. 251- 258 ,(1968)
Kimiyasu Yamazaki, Tumor differentiation phenotype in gastric differentiated-type tumors and its relation to tumor invasion and genetic alterations. World Journal of Gastroenterology. ,vol. 12, pp. 3803- 3809 ,(2006) , 10.3748/WJG.V12.I24.3803
Gen Tamura, A. Steven Fleisher, Stephen J. Meltzer, Manel Esteller, Tong Tong Zou, Stephen P. James, Jing Yin, Keith T. Wilson, Suna Wang, James G. Herman, Steven M. Powell, Mun Gan Rhyu, John M. Abraham, Dehe Kong, Kara N. Smolinski, Ying Qiang Shi, Hiroyuki Suzuki, Hypermethylation of the hMLH1 Gene Promoter in Human Gastric Cancers with Microsatellite Instability Cancer Research. ,vol. 59, pp. 1090- 1095 ,(1999)
Su Hyung Hong, Ho Gak Kim, Woon Bok Chung, Eun Young Kim, Jong Young Lee, Sang Mo Yoon, Joong Goo Kwon, Yoon Kyung Sohn, Eun Kyung Kwak, Jung Wan Kim, DNA hypermethylation of tumor-related genes in gastric carcinoma. Journal of Korean Medical Science. ,vol. 20, pp. 236- 241 ,(2005) , 10.3346/JKMS.2005.20.2.236
Junji Komori, Hiroyuki Marusawa, Takafumi Machimoto, Yoko Endo, Kazuo Kinoshita, Tadayuki Kou, Hironori Haga, Iwao Ikai, Shinji Uemoto, Tsutomu Chiba, Activation-induced cytidine deaminase links bile duct inflammation to human cholangiocarcinoma Hepatology. ,vol. 47, pp. 888- 896 ,(2008) , 10.1002/HEP.22125
Toshiyuki Morisawa, Hiroyuki Marusawa, Yoshihide Ueda, Akio Iwai, Il-mi Okazaki, Tasuku Honjo, Tsutomu Chiba, Organ-specific profiles of genetic changes in cancers caused by activation-induced cytidine deaminase expression International Journal of Cancer. ,vol. 123, pp. 2735- 2740 ,(2008) , 10.1002/IJC.23853
Hiroshi Saeki, Shinji Ohno, Mitsuhiro Miyazaki, Koshi Araki, Akinori Egashira, Hidetoshi Kawaguchi, Masayuki Watanabe, Masaru Morita, Keizo Sugimachi, p53 protein accumulation in multiple oesophageal squamous cell carcinoma: relationship to risk factors. Oncology. ,vol. 62, pp. 175- 179 ,(2002) , 10.1159/000048264
Chang Jae Kim, Jae Hwi Song, Yong Gu Cho, Zhang Cao, Su Young Kim, Suk Woo Nam, Jung Young Lee, Won Sang Park, Activation-Induced Cytidine Deaminase Expression in Gastric Cancer Tumor Biology. ,vol. 28, pp. 333- 339 ,(2007) , 10.1159/000124239