Nicotinamide (vitamin B3) as an effective antioxidant against oxidative damage in rat brain mitochondria.
作者： J.P. Kamat , T.P.A. Devasagayam
DOI: 10.1179/135100099101534882
关键词:
摘要: Nicotinamide (vitamin B3) an endogenous metabolite, showed significant inhibition of oxidative damage induced by reactive oxygen species (ROS) generated ascorbate-Fe2+ and photosensitization systems in rat brain mitochondria. It protected against both protein oxidation lipid peroxidation, at millimolar concentrations. Inhibition was more pronounced proteins than peroxidation lipids. Chemically related compounds, tryptophan isonicotinic acid, comparable inhibitory properties. The protective effect observed, biologically relevant concentrations, with nicotinamide that the antioxidants ascorbic acid alpha-tocopherol. Hence our studies suggest can be considered as a potent antioxidant capable protecting cellular membranes brain, which is highly susceptible to prooxidants, ROS.
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