S-phase kinase-associated protein 2 promotes cell growth and motility in osteosarcoma cells.
作者： Lu Ding , Rong Li , Rongxin Sun , Yang Zhou , Yubo Zhou
DOI: 10.1080/15384101.2017.1346760
关键词:
摘要: Skp2 (S-phase kinase-associated protein 2) plays an oncogenic role in a variety of human cancers. However, the function osteosarcoma (OS) is elusive. Therefore, current study, we explore whether exerts its OS. The cell growth, apoptosis, invasion and cycle were measured OS cells after overexpression. We found that overexpression enhanced inhibited apoptosis cells. Moreover, observed upregulation accelerated progression Furthermore, ability migration was overexpressing Mechanically, our Western blotting data suggested decreased expression E-cadherin, Foxo1, p21, p57, but increased MMP-9 In conclusion, study demonstrated exhibited cells, suggesting inhibition may be novel approach for treatment
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