Symptoms of Raynaud's syndrome in patients with fibromyalgia. A study utilizing the Nielsen test, digital photoplethysmography, and measurements of platelet α2‐adrenergic receptors

摘要: Twenty-nine female patients with fibromyalgia were questioned about symptoms of cold intolerance and Raynaud's syndrome; objective documentation cold-induced vasospasm was obtained by a Nielsen test. Twelve (41%) had abnormal test results, 11 (38%) elevated levels platelet alpha 2-adrenergic receptors. There positive correlation between the percentage change in finger systolic pressure on cooling (Nielsen test) number poor syndrome an result. Digital photoplethysmography showed normal waveform 2 3 patients. We hypothesize that subgroup have up-regulation receptors as cause their exaggerated reaction to cold.