Morphometric techniques in the evaluation of pulmonary vascular changes due to congenital heart disease.

摘要: Summary Open lung biopsy is performed in patients with congenital heart disease to determine the suitability for surgical correction. Controversy exists as whether arterial density can be graded certainty. We studied influence on grading (Heath-Edwards) of two morphometric techniques. Lung tissue from 14 controls and specimens 80 atrial septal defect (n=10), ventricular (n=27), complete atrioventricular canal miscellaneous lesions (n=8) tetralogy Fallot were analyzed a planimetric method. Additionally, wall thickness was determined 52 by distance measurements. The ratio alveoli/arteries per area measured. Medial “increased” measurements 15% cases where data showed normal thickness. varied up 43% mean. Hemodynamic obtained at median (range) time 2 months (1 day 18 months) before operation did not correlate morphologic findings. In 27 hemodynamic recorded 1 year (3 days 44 after operation. Intimal fibrosis occupying more than 0% vessel lumen associated persistent high pulmonary vascular resistance. conclude that techniques are useful degree advanced lesions. Arterial cannot adequate